That depends on the blocker software. Flow uses two types of communication: datatransfer to Salesforce.com and analytics to Mixpanel. The analytics is there to help us improve Flow and make the client even better for you. Flow will continue to work even if you block communication towards Mixpanel. But the other part, the communication to Salesforce.com is essential for Flow to work. If that is blocked we will not be able to show you your CRM-data. So make sure the communication to Salesforce.com is always whitelisted. Ghostery is a popular tracker blocker that works with Flow as it let's you whitelist Salesforce.com.
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